Endocrine Abstracts

Bisphenol A (BPA) is a widely used chemical and belongs to the list of metabolism-disrupting chemicals. BPA is banned in several countries and replaced by others BPA-analogs. We investigate the effects of BPA and 6 BPA-analogs (BPS, BPAF, BPF, BPB and BADGE) on the response of the human melanocortin 4 receptor (MC4R), a receptor involved in food intake and weight control, to its natural ligands. We used HEK293 cells line transiently transfected with human MC4R to determine the...

Introduction: Epidemiological and In vivo experimental studies reveal reprotoxic effects of endocrine disruptors (phthalates (DBP, DEHP) and bisphenol A (BPA)). An inverse association was found between the concentration of these endocrine disruptors and the concentration of INSL3. INSL3, a relaxine peptide, is involved in reproductive function, via its cognate receptor, RXFP2. The aim of this study was to characterize the involvement of RXFP2 in the effects o...

Introduction: The relaxin family peptide receptor 2 (RXFP2) is the receptor for Insulin-like peptide-3 (INSL3). The INSL3/RXFP2 signaling is necessary in the first stage of testis descent. Besides, it is proposed that RXFP2 has a role in bone metabolism or in development of cancers (thyroid, prostate). RXFP2 is a rhodopsin-like G protein-coupled receptors (GPCR). Recently, it has been demonstrated that Drosophila RXFP2 had constitutive activity, i.e., a ligand-independent sign...

Numerous epidemiological studies link exposure to Bisphenol A (BPA) to reproductive function anomalies. Our team recently showed that BPA inhibits the action of Follicle Stimulating Hormone (FSH) on its receptor (FSHR). Water decontamination is achieved by chloration, which leads to the formation of chlorinated derivatives of Bisphenol A (ClXBPA), that may be found in natural environments and biological liquids or organs. In the presence of bromine, the formation of...

Metabolic diseases (type 2 diabetes (T2D) and obesity) prevalence is increasing in the world. This is partly related to a change in lifestyle with an increase of caloric intake and a decrease of physical activity. Environmental causes are also involved among them exposure to bisphenol A (BPA). The mode of action of the latter is unknown. Beyond a suggesting effect relayed by nuclear receptors, we propose that BPA can act by modulating the functionality of G protein-coupled rec...